ICD-10 Code for Right Knee Pain (M25.561): Clinical and Coding Guide
According to the National Institutes of Health (NIH), frequent knee pain affects approximately 25% of adults and is a leading cause of functional limitation and reduced quality of life. Among individuals aged 50 and older, osteoarthritis is identified as the most common underlying cause. While knee pain may originate from various musculoskeletal or systemic conditions, it often presents initially without a confirmed diagnosis, requiring careful clinical assessment and accurate symptom-level coding.
The ICD-10 code for right knee pain (M25.561) is a classification under the musculoskeletal chapter used to document pain localized to the right knee during the initial evaluation phase. It enables providers to support medical necessity for diagnostic imaging, specialist referrals, and conservative management prior to confirming a more specific etiology. Proper usage of M25.561 ensures alignment between clinical findings, documentation, and payer requirements.
What You’ll Learn
In this guide, you’ll understand how to:
- Accurately assign ICD-10 code M25.561 for right knee pain
- Distinguish symptom-level coding from diagnosis-based coding (e.g., arthritis, meniscal tears)
- Justify diagnostic services such as imaging or orthopedic referrals
- Apply documentation standards that reduce audit risk
- Avoid denials by aligning pain-related complaints with medical necessity indicators
What Is Right Knee Pain?
Right knee pain refers to localized discomfort in the right knee joint, which may present as dull, sharp, intermittent, or persistent pain. It may be triggered by:
- Mechanical strain (overuse or poor alignment)
- Traumatic injury (ligament sprain, meniscal tear)
- Inflammatory conditions (bursitis, synovitis)
- Degenerative changes (osteoarthritis)
- Referred pain from the hip or lumbar spine
While some cases are acute and self-limiting, chronic or function-limiting pain typically requires a structured workup involving physical exams, imaging, and potential specialist referrals.
What Is the ICD-10 Code for Right Knee Pain?
The official ICD-10 code for right knee pain is M25.561 – Pain in right knee.
This code is part of the ICD-10-CM system (International Classification of Diseases, 10th Revision, Clinical Modification) used in the U.S. for standardized diagnosis coding across all healthcare settings. M25.561 is categorized under Chapter 13, which focuses on Diseases of the Musculoskeletal System and Connective Tissue. This chapter includes all conditions that affect joints, bones, muscles, tendons, and connective tissues.
When to Use ICD-10 code for right knee pain (M25.561)
Use M25.561 in the following scenarios:
- Primary complaint is right knee pain, with no known underlying condition yet established
- Patient presents for initial evaluation or second opinion regarding right knee symptoms
- Supporting diagnostic workup (X-rays, MRI, labs) is pending
- Pain is functional and affects mobility, prompting documentation for therapy or imaging referrals
Avoid using M25.561 if the pain has already been diagnosed as a condition like M17.11 (Unilateral primary osteoarthritis, right knee) or S83.241A (Sprain of medial collateral ligament of right knee, initial encounter).
Right Knee Pain vs. Specific Knee Diagnoses: Coding Differences
| Criteria | Symptom Code – M25.561 | Specific Diagnosis Codes |
|---|---|---|
| ICD-10 Code | M25.561 | e.g., M17.11, S83.241A |
| Clinical Certainty | Symptom only | Diagnosed condition |
| Supporting Workup | In progress | Confirmed via imaging/labs |
| Management Plan | Conservative or refer | Disease-specific (e.g., injections, surgery) |
| Documentation Needed | Symptom description, location | Diagnostic evidence (e.g., radiology, tests) |
Linking M25.561 to Diagnostic Testing and Services
Using ICD-10 code M25.561 supports medical necessity for ordering:
- X-ray or MRI of the right knee
- Physical therapy referral for pain management
- Orthopedic consultation for further evaluation
- Medication management (e.g., NSAIDs, corticosteroids)
Example Chart Note:
HPI: Patient presents with 3-month history of progressive right knee pain, worse with flexion and weight-bearing. No trauma reported.
PE: Tenderness along medial joint line; mild effusion noted.
Plan: Order X-ray and refer to orthopedics.
ICD-10 Code: M25.561 – Pain in right knee
Pro-MBS Best Practices for Documenting Right Knee Pain (ICD-10: M25.561)
Pediatric Considerations for Right Knee Pain
In children and adolescents, right knee pain may be attributed to:
- Osgood-Schlatter disease
- Juvenile idiopathic arthritis
- Growth plate stress or trauma
Use M25.561 only when no definitive pediatric condition is diagnosed. Once confirmed, use age-appropriate diagnosis codes from the M08 or S80–S89 ICD-10 blocks as appropriate.
Can M25.561 Be a Primary Diagnosis?
✅ Yes. M25.561 can be used as the primary diagnosis when the patient's main complaint is right knee pain, and no specific pathology is identified during the encounter.
❌ No. Do not use as primary if a more specific diagnosis has already been made or if the visit is a follow-up for a previously documented condition.
How Pro-MBS Supports Pain-Related ICD-10 Coding Accuracy
Our Pro-MBS team specializes in musculoskeletal coding and documentation support, ensuring pain-related complaints like right knee pain are accurately captured and properly linked to services rendered. Our expert team helps providers:
- Ensure correct use of ICD-10 M25.561 during evaluation phases
- Align clinical documentation with CPT codes for imaging, therapy, or specialist referrals
- Minimize payer denials through compliance-checked coding workflows
- Guide transitions from symptom-based to diagnosis-based coding when warranted
